Cochrane · systematic review · CD008276
Pharmacotherapy for hypertension in adults aged 18 to 59 years
Musini, VM, Gueyffier, F, Puil, L, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antihypertensive drug therapy compared to control for hypertension in adults aged 18 to 59 years
Population: adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Antihypertensive drug therapy vs control | RR 0.94 [0.77, 1.13] | 5 studies · 16776 participants | Low |
Total cardiovascular mortality + morbidity Antihypertensive drug therapy vs control | RR 0.78 [0.67, 0.91] | 6 studies · 17278 participants | Low |
Cerebrovascular mortality + morbidity Antihypertensive drug therapy vs control | RR 0.46 [0.34, 0.64] | 6 studies · 17278 participants | Low |
Coronary heart disease mortality + morbidity Antihypertensive drug therapy vs control | RR 0.99 [0.82, 1.19] | 4 studies · 16241 participants | Low |
Withdrawal due to adverse events Antihypertensive drug therapy vs control | RR 4.82 [1.67, 13.92] | 3 studies · 1223 participants | Very low |
Decrease in SBP5 at end of 1 year Antihypertensive drug therapy vs control | no estimate extracted | 3 studies · 14845 participants | Very low |
Decrease in DBP6 at end of 1 year Antihypertensive drug therapy vs control | no estimate extracted | 4 studies · 15857 participants | Very low |