Cochrane · systematic review · CD012569
Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension
Wang, GM, Li, LJ, Tang, WL, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Renin inhibitors compared to ACE inhibitors for primary hypertension
Population: people with primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Renin inhibitors vs ACE inhibitors | RR 1.05 [0.93, 1.18] | 5 studies · 5962 participants | Low Downgraded: risk of bias |
Fatal or non‐fatal myocardial infarction Renin inhibitors vs ACE inhibitors | RR 0.86 [0.22, 3.39] | 2 studies · 957 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Renin inhibitors vs ACE inhibitors | RR 0.98 [0.93, 1.03] | 10 studies · 6007 participants | Moderate Downgraded: risk of bias |
Fatal or non‐fatal serious adverse events Renin inhibitors vs ACE inhibitors | RR 1.21 [0.89, 1.64] | 10 studies · 6007 participants | Low Downgraded: risk of bias, imprecision |
Withdrawal due to adverse effects (WDAE) Renin inhibitors vs ACE inhibitors | RR 0.85 [0.68, 1.06] | 10 studies · 6008 participants | Low Downgraded: risk of bias, imprecision |
SBP Renin inhibitors vs ACE inhibitors | no estimate extracted | 9 studies · 5001 participants | Low Downgraded: risk of bias, publication bias |
DBP Renin inhibitors vs ACE inhibitors | no estimate extracted | 9 studies · 5001 participants | Low Downgraded: risk of bias, publication bias |