Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

124 questions · 128 findings · 65 reviews

No studies found 23 · 18%GRADE not reported 6 · 4.7%Very low 47 · 36.7%Low 35 · 27.3%Moderate 14 · 10.9%High 3 · 2.3%

Interrupted vs uninterrupted anticoagulation therapy

Composite endpoint of thromboembolic events (stroke or systemic embolism), major bleeding events, and all‐cause mortality · adults with arrhythmias undergoing catheter ablation

Interrupted may leads to lower composite endpoint of thromboembolic events (stroke or systemic… compared with uninterrupted anticoagulation therapy (low certainty).

1 finding from 1 review

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention showed no clear difference in all‐cause mortality Median (low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for participants with AMI · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for participants with AMI compared with air (very low certainty).

1 finding from 1 review

Early vs deferred AST

Time to death from any cause (here: overall mortality at 12‐month · advanced hormone‐sensitive prostate cancer

Early probably leads to lower time to death of any cause (here: all‐cause mortality at 5 years) compared with deferred AST (moderate certainty).

1 finding from 1 review