Question · asked by 1 review

DFP and DFO vs DFP and DFX: Death by end of trial

Population
Not specified
Intervention
DFP and DFO
Comparison
DFP and DFX
Outcome
Death by end of trial

It is very uncertain whether summary of findings: Comparison 7 ‐ deferiprone (DFP) plus… changes all‐cause mortality ‐ at 1 year ‐ trial end compared with DFP plus deferasirox (DFX) (very low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Summary of findings: Comparison 7 ‐ deferiprone (DFP) plus deferoxamine (DFO) vs DFP plus deferasirox (DFX)
All‐cause mortality ‐ at 1 year ‐ trial end
It is very uncertain whether summary of findings: Comparison 7 ‐ deferiprone (DFP) plus… changes all‐cause mortality ‐ at 1 year ‐ trial end compared with DFP plus deferasirox (DFX) (very low certainty).
Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or… (2023) · Cochrane Headline outcomes only
RD 01 study · 96 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia
2023 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed

The same intervention and outcome, asked in another population or against another comparator.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.