Cochrane · systematic review · CD003506
Early versus deferred standard androgen suppression therapy for advanced hormone‐sensitive prostate cancer
Kunath, F, Jensen, K, Pinart, M, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early compared to deferred AST for advanced hormone‐sensitive prostate cancer
Population: advanced hormone‐sensitive prostate cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to death of any cause (here: all‐cause mortality at 5 years) Early vs deferred AST | HR 0.82 [0.75, 0.9] | 10 studies · 4767 participants | Moderate Downgraded: risk of bias |
Serious adverse events Early vs deferred AST | RR 1.05 [0.95, 1.16] | 5 studies · 10575 participants | Low Downgraded: risk of bias, imprecision |
Time to death from prostate cancer (here: prostate cancer mortality at 5 years) Early vs deferred AST | HR 0.69 [0.57, 0.84] | 7 studies · 3677 participants | Moderate Downgraded: risk of bias, imprecision |
Skeletal events Early vs deferred AST | RR 0.37 [0.17, 0.8] | 3 studies · 2209 participants | Low Downgraded: risk of bias, imprecision |
Fatigue Early vs deferred AST | RR 1.41 [1.23, 1.62] | 2 studies · 8209 participants | Low Downgraded: risk of bias, imprecision |
Heart failure Early vs deferred AST | RR 1.9 [1.09, 3.33] | 1 study · 1214 participants | Low Downgraded: risk of bias, imprecision |
Global quality of life Early vs deferred AST | no estimate extracted | 1 study · 285 participants | Moderate Downgraded: risk of bias, imprecision |