Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 51 findings · 23 reviews

No studies found 22 · 43.1%GRADE not reported 1 · 2%Very low 16 · 31.4%Low 8 · 15.7%Moderate 4 · 7.8%High 0 · 0%

Sclerotherapy vs no intervention

Serious adverse events and liver‐related morbidity: incidence of gastric varices · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes serious adverse events and liver‐related morbidity: incidence of… compared with no intervention (very low certainty).

1 finding from 1 review

Sclerotherapy vs no intervention

Serious adverse events and liver‐related morbidity: incidence of bleeding from gastric varices · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes serious adverse events and liver‐related morbidity: incidence of… compared with no intervention (very low certainty).

1 finding from 1 review

Comprehensive geriatric assessment (CGA) vs usual care

Serious adverse events (falls) Median · older people at risk of poor health outcomes

It is very uncertain whether comprehensive Geriatric Assessment changes serious adverse events (falls) Median compared with usual care (very low certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

Serious adverse events (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in serious adverse events (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… showed no clear difference in incidence of serious adverse events compared with placebo (low certainty).

1 finding from 1 review