Cochrane · systematic review · CD011573
Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
Gattini, D, Cifuentes, LI, Torres-Robles, R, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 1 · 12.5%Very low 6 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Sclerotherapy compared to no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
Population: primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Sclerotherapy vs no intervention | RR 1.04 [0.44, 2.5] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Upper gastrointestinal bleeding Sclerotherapy vs no intervention | RR 0.46 [0.26, 0.83] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events and liver‐related morbidity: incidence of congestive hypertensive gastropathy Sclerotherapy vs no intervention | RR 2.48 [0.69, 8.84] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events and liver‐related morbidity: incidence of gastric varices Sclerotherapy vs no intervention | RR 1.11 [0.36, 3.43] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events and liver‐related morbidity: incidence of bleeding from gastric varices Sclerotherapy vs no intervention | RR 6.51 [0.34, 123.06] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Sclerotherapy vs no intervention | no estimate extracted | NR | No studies |
Oesophageal variceal bleeding Sclerotherapy vs no intervention | RR 0.13 [0.04, 0.42] | 1 study · 108 participants | Very low Downgraded: risk of bias, imprecision |
Non‐serious adverse events Sclerotherapy vs no intervention | no estimate extracted | 1 study · 108 participants | Ungraded |