Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

237 questions · 243 findings · 108 reviews · Headline outcomes only

No studies found 65 · 26.7%GRADE not reported 14 · 5.8%Very low 88 · 36.2%Low 46 · 18.9%Moderate 26 · 10.7%High 4 · 1.6%

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Surgically‐related severe adverse effects (grade 3+) ‐ postoperative G3+ events (within 30 days of surgery) · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) probably leads to lower surgically‐related severe adverse effects (grade 3+) ‐ postoperative… compared with surgery followed by chemotherapy (PDS) (moderate certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Adverse events · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes adverse events compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Proportion of women with adverse events Endometrial ablation versus LNG‐IUS. At one year · women with heavy menstrual bleeding

Surgery probably leads to lower proportion of women with adverse events Endometrial ablation versus… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Adverse events · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Subfascial endoscopic perforator vein surgery (SEPS) + saphenous surgery vs saphenous surgery

Adverse events · people with venous leg ulcers

It is very uncertain whether subfascial endoscopic perforator vein surgery (SEPS) + saphenous… changes adverse events compared with saphenous surgery (very low certainty).

1 finding from 1 review

Endoscopic surgery vs open surgery

Adverse events (infection, dysaesthesia) · patients with trigger finger

It is very uncertain whether endoscopic surgery changes adverse events (infection, dysaesthesia) compared with open surgery (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures
1 finding from 1 review

iMRI image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews