Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 35 findings · 14 reviews · Acute Respiratory Infections

No studies found 2 · 5.7%GRADE not reported 3 · 8.6%Very low 6 · 17.1%Low 6 · 17.1%Moderate 18 · 51.4%High 0 · 0%

Xylitol vs control

Gastrointestinal adverse events · preventing acute otitis media in children up to 12 years of age

Xylitol showed no clear difference in gastrointestinal‐related adverse events compared with control (moderate certainty).

3 findings from 1 review

Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care

Adverse events · children aged up to 16 years with ARTIs

It is very uncertain whether homeopathic medicinal products (non‐individualised treatment) changes adverse events compared with placebo or usual care (very low certainty).

1 finding from 1 review

Homeopathic medicinal products (individualised treatment) vs placebo or usual care

Adverse events · children aged up to 16 years with ARTIs

Homeopathic medicinal products (individualised treatment) showed no clear difference in adverse events compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events (number of adverse events/person/year) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention showed no clear difference in adverse events (number of adverse events/person/year) (low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ death Clinical criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ deathClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review