Cochrane · systematic review · CD015306
Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Cheng, X, Li, D, Yang, C, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Vitamin A supplements compared to placebo for preventing acute URTIs in children up to seven years of age
Population: children up to the age of 7 at risk of upper respiratory tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of acute URTIs during the study period (the number of acute URTIs over a period of time) Summary of findings table ‐ Vitamin A supplements vs placebo | RR 1 [0.92, 1.09] | 3 studies · 22668 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of acute URTIs during the study period (proportion of participants with an acute URTI) Summary of findings table ‐ Vitamin A supplements vs placebo | no estimate extracted | 2 studies · 15535 participants | Low Downgraded: risk of bias |
Adverse events Summary of findings table ‐ Vitamin A supplements vs placebo | no estimate extracted | 1 study · 116 participants | Very low Downgraded: risk of bias, imprecision |
Severity of subjective symptoms (mean duration of acute URTI) Summary of findings table ‐ Vitamin A supplements vs placebo | no estimate extracted | 2 studies · 290 participants | Very low Downgraded: risk of bias, imprecision |
Time to occurrence of acute URTI ‐ not reported Summary of findings table ‐ Vitamin A supplements vs placebo | no estimate extracted | NR | No studies |
Number of cases with complications ‐ not reported Summary of findings table ‐ Vitamin A supplements vs placebo | no estimate extracted | NR | No studies |
Rate of hospitalisation ‐ not reported Summary of findings table ‐ Vitamin A supplements vs placebo | no estimate extracted | NR | No studies |