Cochrane · systematic review · CD010056
Post‐exposure passive immunisation for preventing measles
Young, MK, Nimmo, GR, Cripps, AW, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 40%Very low 0 · 0%Low 0 · 0%Moderate 4 · 40%High 2 · 20%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Immunoglobulin compared to no treatment for preventing measles
Population: susceptible people exposed to measles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Measles cases ‐ convalescent serum Immunoglobulin vs no treatment | RR 0.21 [0.15, 0.29] | 3 studies · 301 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Measles cases ‐ adult serum Immunoglobulin vs no treatment | RR 0.52 [0.45, 0.59] | 2 studies · 586 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Measles cases ‐ gamma globulin Immunoglobulin vs no treatment | RR 0.17 [0.08, 0.36] | 2 studies · 545 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Mortality due to measles Immunoglobulin vs no treatment | RR 0.24 [0.13, 0.44] | 3 studies · 893 participants | High |
Complications due to measles Immunoglobulin vs no treatment | RR 0.18 [0.05, 0.6] | 3 studies · 832 participants | Moderate Downgraded: risk of bias, imprecision, publication bias |
Adverse events Immunoglobulin vs no treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Gamma globulin compared to serum for preventing measles
Population: susceptible children exposed to measles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Measles cases Gamma globulin vs serum | RR 0.56 [0.46, 0.69] | 2 studies · 702 participants | High |
Mortality due to measles Gamma globulin vs serum | no estimate extracted | 0 studies · 0 participants | Ungraded |
Complications due to measles Gamma globulin vs serum | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse events Gamma globulin vs serum | no estimate extracted | 0 studies · 0 participants | Ungraded |