Cochrane · systematic review · CD010586
Post‐exposure passive immunisation for preventing rubella and congenital rubella syndrome
Young, MK, Cripps, AW, Nimmo, GR, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Gamma‐globulin compared to control (saline or no treatment) for preventing rubella or congenital rubella syndrome
Population: susceptible people exposed to rubella
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Rubella cases Initial meta‐analysis ‐ clinical diagnosis or serology +/‐ virus isolation +/‐ clinical signs Gamma‐globulin vs control (saline or no treatment) | RR 0.61 [0.45, 0.83] | 11 studies · 389 participants | Moderate Downgraded: risk of bias, inconsistency |
Subgroup: rubella cases Estimated dose 0.027 to 0.037 ml/lb11 Clinical diagnosis by 2 physicians Gamma‐globulin vs control (saline or no treatment) | RR 1.6 [0.57, 4.52] | 1 study · 24 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Subgroup: rubella cases Estimated dose 0.1 to 0.15 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs Gamma‐globulin vs control (saline or no treatment) | RR 0.53 [0.29, 0.99] | 3 studies · 37 participants | High |
Subgroup: rubella cases Estimated dose 0.2 to 0.5 ml/lb11 Serology +/‐ virus isolation +/‐ clinical signs Gamma‐globulin vs control (saline or no treatment) | RR 0.2 [0.04, 1] | 3 studies · 28 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cases of congenital rubella infection ‐ not measured Gamma‐globulin vs control (saline or no treatment) | no estimate extracted | NR | No studies |
Cases of congenital rubella syndrome ‐ not measured Gamma‐globulin vs control (saline or no treatment) | no estimate extracted | NR | No studies |
Adverse events ‐ not measured Gamma‐globulin vs control (saline or no treatment) | no estimate extracted | NR | No studies |