Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Preformed crown (any material; conventional technique or Hall Technique) vs Filling (any material; with or without complete carious tissue excavation; with or without pulp treatment)

Adverse events: gingival bleeding · Children with decayed primary molar teeth

Preformed crown (any material; conventional technique or Hall… showed no clear difference in adverse events: gingival bleeding compared with filling (any material; with or without complete carious tissue…; GRADE not reported.

2 findings from 1 review

Duodenum‐preserving pancreatic resection vs pancreaticoduodenectomy

Adverse events (number of adverse events) · people requiring surgery for chronic pancreatitis

It is very uncertain whether duodenum‐preserving pancreatic resection changes adverse events (number of adverse events) compared with pancreaticoduodenectomy (very low certainty).

1 finding from 1 review

On‐demand deprescribing vs continued use

Adverse drug withdrawal events ‐ esophagitis (endoscopic findings) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher adverse drug withdrawal events ‐ esophagitis (endoscopic findings) compared with continued use (low certainty).

1 finding from 1 review

Preoperative education vs usual care

Total number of serious adverse events (infection, thrombosis, other serious adverse events · patients with knee replacement surgery

Preoperative education showed no clear difference in total number of serious adverse events (infection, thrombosis, other… compared with usual care (low certainty).

1 finding from 1 review

Preoperative education vs usual care

Total number of serious adverse events (infection, thrombosis, other serious adverse events · hip replacement

It is very uncertain whether preoperative education changes total number of serious adverse events (infection, thrombosis, other… compared with usual care (very low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review

Antidepressants vs placebo

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes adverse events: death ‐ at end of treatment Analysis 1.12 compared with placebo (very low certainty).

1 finding from 1 review