Cochrane · systematic review · CD000020
Anti‐D administration in pregnancy for preventing Rhesus alloimmunisation
McBain, RD, Crowther, CA, Middleton, P · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 1 · 14.3%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anti‐D administration in pregnancy compared with no treatment for pregnancy for preventing Rhesus alloimmunisation
Population: Rh‐negative women without anti‐D antibodies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of Rhesus D alloimmunisation during pregnancy Anti‐D administration in pregnancy vs no treatment | RR 0.42 [0.15, 1.17] | 2 studies · 3902 participants | Low |
Incidence of Rhesus D alloimmunisation postpartum (at birth of Rh‐positive infant and at Anti‐D administration in pregnancy vs no treatment | RR 0.39 [0.1, 1.62] | 2 studies · 2048 participants | Low |
Incidence of Rhesus D alloimmunisation in a subsequent pregnancy Anti‐D administration in pregnancy vs no treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Incidence of positive Kleihauer test (at 32 to 35 weeks' gestation) Anti‐D administration in pregnancy vs no treatment | RR 0.6 [0.41, 0.88] | 1 study · 1884 participants | Low Downgraded: imprecision |
Incidence of positive Kleihauer test (at birth of a Rh‐positive infant) Anti‐D administration in pregnancy vs no treatment | RR 0.6 [0.46, 0.79] | 1 study · 1189 participants | Low Downgraded: imprecision |
Neonatal jaundice Anti‐D administration in pregnancy vs no treatment | RR 0.26 [0.03, 2.3] | 1 study · 1882 participants | Very low Downgraded: imprecision |
Adverse events attributed to anti‐D treatment Anti‐D administration in pregnancy vs no treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |