Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with possible related Severe Adverse Events ‐ 24 months11 · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP regimen administered to infants for 14 weeks changes infants with possible related Severe Adverse Events ‐ 24 months11 compared with sdNVP plus ZDV (1week) (very low certainty).

1 finding from 1 review

Four per cent chlorhexidine + hand hygiene promotion vs usual care

Authors reported adverse outcomes (events without hospitalisation) · Neonates and caregivers

It is very uncertain whether four per cent chlorhexidine + hand hygiene promotion changes authors reported adverse outcomes (events without hospitalisation) compared with usual care (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

acceptability ‐ drop‐outs due to adverse events: post‐intervention · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes acceptability ‐ drop‐outs due to adverse events: post‐intervention compared with placebo (very low certainty).

1 finding from 1 review

Integrated securement dressings vs standard polyurethane

Adverse events assessed during catheter dwell or on product removal · people with arterial catheter dressing and securement

Integrated securement dressings showed no clear difference in adverse events assessed during catheter dwell or on product removal compared with standard polyurethane (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers

Mothers with Severe Adverse Events Requiring Treatment Modification · HIV‐infected mothers and their breastfeeding infants

It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes mothers with Severe Adverse Events Requiring Treatment Modification compared with an extended ZDV/3TC/ABC administered to mothers (very low certainty).

1 finding from 1 review

Standard polyurethane plus sutureless securement devices vs standard polyurethane

Adverse events assessed during catheter dwell and on product removal · people with arterial catheter dressing and securement

It is very uncertain whether standard polyurethane plus sutureless securement devices changes adverse events assessed during catheter dwell and on product removal compared with standard polyurethane (very low certainty).

1 finding from 1 review

Standard polyurethane plus tissue adhesive vs standard polyurethane

Adverse events assessed during catheter dwell and on product removal · people with arterial catheter dressing and securement

It is very uncertain whether standard polyurethane plus tissue adhesive changes adverse events assessed during catheter dwell and on product removal compared with standard polyurethane (very low certainty).

1 finding from 1 review

Dextrose gel vs placebo

Adverse events# (e.g. choking or vomiting at time of administration) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in adverse events# (e.g. choking or vomiting at time of administration) compared with placebo (moderate certainty).

1 finding from 1 review

Heated tobacco use vs cigarette smoking

Serious adverse events – measured by self‐report and medical records · people who smoke

It is very uncertain whether heated tobacco use changes serious adverse events – measured by self‐report and medical records compared with cigarette smoking (very low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ any local symptom Clinical criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to higher participants with adverse events ‐ any local symptomClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Adverse events (maternal) ‐ skin irritation or allergic skin reaction · women undergoing caesarean section

It is very uncertain whether chlorhexidine gluconate changes adverse events (maternal) ‐ skin irritation or allergic skin reaction compared with povidone iodine (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse eventsClinical manifestation and laboratory examination · people with acute herpes zoster (within 7 days of onset of rash)

It is very uncertain whether the intervention changes serious adverse eventsClinical manifestation and laboratory… (very low certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Vomiting · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in adverse events during first 48‐72 hours post supplementation ‐… compared with control (high certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Adverse effects of any severity (systemic symptoms) · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to higher participants with adverse events ‐ any systemic symptomClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Adverse effects: diarrhoea 48 to 72 hours · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in adverse events during first 48‐72 hours post supplementation ‐… compared with control (low certainty).

1 finding from 1 review