Cochrane · systematic review · CD012152
Oral dextrose gel to prevent hypoglycaemia in at‐risk neonates
Roberts, L, Lin, L, Alsweiler, J, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 3 · 42.9%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsDextrose gel compared with placebo for prevention of hypoglycaemia in newborn infants
Population: newborn infants at risk of neonatal hypoglycaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypoglycaemia (investigator‐defined) Dextrose gel vs placebo | RR 0.87 [0.79, 0.95] | 2 studies · 2548 participants | High |
Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... Dextrose gel vs placebo | RR 1 [0.59, 1.68] | 2 studies · 1554 participants | Low Downgraded: imprecision |
Receipt of treatment for hypoglycaemia during initial hospital stay (investigator‐defined, any treatment ‐ oral dextrose gel, intravenous dextrose, or other drug therapy) during initial hospital stay (yes/no) Dextrose gel vs placebo | RR 0.89 [0.79, 1] | 2 studies · 2548 participants | Moderate Downgraded: imprecision, inconsistency |
Receipt of intravenous treatment for hypoglycaemia (yes/no) Dextrose gel vs placebo | RR 1.01 [0.68, 1.49] | 2 studies · 2548 participants | Moderate Downgraded: imprecision |
Adverse events# (e.g. choking or vomiting at time of administration) Dextrose gel vs placebo | RR 1.22 [0.64, 2.33] | 2 studies · 2510 participants | Moderate Downgraded: imprecision |
Separation from mother for treatment of hypoglycaemia (infant nursed in an environment that is not in the same room as the mother, e.g. for NICU admission or the like) (yes/no) Dextrose gel vs placebo | RR 1.12 [0.81, 1.55] | 2 studies · 2548 participants | Low Downgraded: imprecision |
Breastfeeding (exclusive after discharge) ‐ not reported (WHO 2008 definition (yes/no)) Dextrose gel vs placebo | no estimate extracted | NR | No studies |