Cochrane · systematic review · CD003295
Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer
van den Bosch, CH, van Woensel, J, van de Wetering, MD · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsSummary of findings table
Population: adults and children diagnosed with an oncologic disease with a newly‐inserted long‐term CVC who were at risk of neutropenia due to chemotherapy or disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Antibiotics prior to long‐term CVC insertion versus control: catheter‐related infections | Risk ratio 0.67 [0.32, 1.43] | 5 studies · 648 participants | Moderate Downgraded: inconsistency |
Antibiotic versus heparin only lock/flush solution: catheter‐related infections | Rate ratio 0.47 [0.26, 0.85] | 5 studies · 443 participants | Moderate Downgraded: imprecision, inconsistency |
Antibiotic versus heparin only lock/flush solution: adverse events | no estimate extracted | 3 studies · 300 participants | Low Downgraded: imprecision, inconsistency |