Cochrane · systematic review · CD003295

Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer

van den Bosch, CH, van Woensel, J, van de Wetering, MD · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Gynaecological, Neuro-oncology and Orphan Cancer2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings table

Population: adults and children diagnosed with an oncologic disease with a newly‐inserted long‐term CVC who were at risk of neutropenia due to chemotherapy or disease

CD003295.PUB4 (current) · 3 questions

Outcome	Effect	Evidence	Status / GRADE
Antibiotics prior to long‐term CVC insertion versus control: catheter‐related infections	Risk ratio 0.67 [0.32, 1.43]	5 studies · 648 participants	Moderate Downgraded: inconsistency
Antibiotic versus heparin only lock/flush solution: catheter‐related infections	Rate ratio 0.47 [0.26, 0.85]	5 studies · 443 participants	Moderate Downgraded: imprecision, inconsistency
Antibiotic versus heparin only lock/flush solution: adverse events	no estimate extracted	3 studies · 300 participants	Low Downgraded: imprecision, inconsistency

Summary of findings: prophylactic antibiotics before long‐term CVC insertion

Population: adults with a newly inserted long‐term CVC who were at risk of neutropenia due to chemotherapy or disease

CD003295.PUB3 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Catheter‐related sepsis	RR 0.72 [0.33, 1.58]	5 studies · 360 participants	Moderate

Summary of findings: antibiotic and heparin versus heparin only flush or lock solution

Population: adults and children with a newly inserted long‐term CVC who were at risk of neutropenia due to chemotherapy or disease

CD003295.PUB3 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Catheter‐related sepsis Summary of findings: antibiotic and heparin vs heparin only flush or lock solution	RR 0.47 [0.28, 0.8]	6 studies · 468 participants	Moderate