Cochrane · systematic review · CD011246
Prevention of depression in adults with long‐term physical conditions
Kampling, H, Baumeister, H, Bengel, J, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 5 · 31.3%Very low 9 · 56.3%Low 2 · 12.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Psychological interventions compared to treatment as usual in the prevention of the incidence of depression in adults with long‐term physical conditions
Population: adults with long‐term physical conditions (18 years or older)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of depression ‐ post‐intervention: 0 months Psychological interventions vs treatment | OR 0.43 [0.2, 0.95] | 1 study · 194 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Incidence of depression ‐ short term: < 6 months Psychological interventions vs treatment | OR 0.71 [0.36, 1.38] | 1 study · 190 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Incidence of depression ‐ medium term: 6‐12 months Psychological interventions vs treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Incidence of depression ‐ long term: > 12 months Psychological interventions vs treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
Tolerability ‐ total number of adverse events Psychological interventions vs treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
acceptability ‐ drop‐outs due to adverse events Psychological interventions vs treatment | no estimate extracted | 0 studies · 0 participants | Ungraded |
acceptability ‐ drop‐outs due to any cause: post‐intervention Psychological interventions vs treatment | OR 5.21 [1.11, 24.4] | 1 study · 206 participants | Low Downgraded: risk of bias, imprecision, indirectness, publication bias |
acceptability ‐ drop‐outs due to any cause: < 6 months Psychological interventions vs treatment | OR 1.67 [0.58, 4.77] | 1 study · 206 participants | Low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Pharmacological interventions compared to placebo in the prevention of the incidence of depression in adults with long‐term physical conditions
Population: adults with long‐term physical conditions (18 years or older)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of depression ‐ post‐intervention: 0 months Pharmacological interventions vs placebo | OR 0.31 [0.2, 0.49] | 9 studies · 814 participants | Very low Downgraded: indirectness |
Incidence of depression ‐ short‐term: < 6 months Pharmacological interventions vs placebo | OR 0.44 [0.08, 2.46] | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Incidence of depression ‐ medium‐term: 6‐12 months Pharmacological interventions vs placebo | OR 0.81 [0.23, 2.82] | 3 studies · 233 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Incidence of depression ‐ long‐term: >12 months Pharmacological interventions vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
tolerability ‐ total number of adverse events Pharmacological interventions vs placebo | no estimate extracted | 5 studies · 5 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
acceptability ‐ drop‐outs due to adverse events: post‐intervention Pharmacological interventions vs placebo | OR 2.05 [1.07, 3.89] | 5 studies · 561 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
acceptability ‐ drop‐outs due to any cause: post‐intervention Pharmacological interventions vs placebo | OR 1.13 [0.73, 1.73] | 9 studies · 962 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
acceptability ‐ drop‐outs due to any cause: 6‐12 months Pharmacological interventions vs placebo | OR 1.13 [0.69, 1.86] | 3 studies · 327 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |