Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Adverse effects requiring withdrawal/discontinuation of study medication · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).

1 finding from 1 review

Induced hypertension vs placebo or no intervention

Proportion of participants with ≥ 1 serious adverse events · people with acute subarachnoid haemorrhage

It is very uncertain whether induced hypertension changes proportion of participants with ≥ 1 serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Resin-based fissure sealant vs Fluoride varnish

Safety of sealants and fluoride varnishes (adverse events) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: nitrofurantoin (1) versus trimethoprim (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 may leads to higher adverse events: nitrofurantoin (1) versus trimethoprim (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether psychological therapy changes adverse events: death ‐ at end of treatment (Analysis 2.16) compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events the resulted in discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events the resulted in discontinuation of treatment (very low certainty).

1 finding from 1 review

TDC vs medical therapy

Secondary outcome:total serious adverse events at the end of · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in secondary outcome:total serious adverse events at the end of compared with medical therapy (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events that result in the discontinuation of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events that result in the discontinuation of treatment (very low certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Participants with adverse events Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse eventsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review