Cochrane · systematic review · CD010746
Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty
Zhang, L, Weizer, JS, Musch, DC · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
16
No studies
12
Included studies
NR
No studies 12 · 42.9%Ungraded 0 · 0%Very low 3 · 10.7%Low 5 · 17.9%Moderate 8 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Medication compared with placebo for preventing temporarily increased IOP after laser trabeculoplasty
Population: people with glaucoma receiving LTP
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IOP increase of ≥ 5 mmHg within 2 hours Medication vs placebo | no estimate extracted | 2 studies · 273 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
IOP increase of ≥ 10 mmHg within 2 hours Medication vs placebo | RR 0.05 [0.01, 0.2] | 4 studies · 446 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Mean change in IOP from pre‐LTP within 2 hours Medication vs placebo | no estimate extracted | 4 studies · 151 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
IOP increase of ≥ 5 mmHg between 2 and 24 hours Medication vs placebo | RR 0.17 [0.09, 0.31] | 5 studies · 634 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
IOP increase of ≥ 10 mmHg between 2 and 24 hours Medication vs placebo | RR 0.22 [0.11, 0.42] | 9 studies · 817 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mean change in IOP from pre‐LTP between 2 and 24 hours Medication vs placebo | no estimate extracted | 4 studies · 151 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse events ‐ conjunctival blanching during study period Medication vs placebo | no estimate extracted | 2 studies · 319 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Brimonidine compared with apraclonidine for preventing temporarily increased IOP after laser trabeculoplasty
Population: people with glaucoma receiving LTP
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IOP increase of ≥ 5 mmHg within 2 hours Brimonidine vs apraclonidine | RR 2.28 [0.32, 16.03] | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
IOP increase of ≥ 10 mmHg within 2 hours Brimonidine vs apraclonidine | no estimate extracted | NR | No studies |
Mean change in IOP from pre‐LTP within 2 hours Brimonidine vs apraclonidine | no estimate extracted | 2 studies · 71 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
IOP increase of ≥ 5 mmHg between 2 and 24 hours Brimonidine vs apraclonidine | no estimate extracted | NR | No studies |
IOP increase of ≥ 10 mmHg between 2 and 24 hours Brimonidine vs apraclonidine | no estimate extracted | NR | No studies |
Mean change in IOP from pre‐LTP between 2 and 24 hours Brimonidine vs apraclonidine | no estimate extracted | NR | No studies |
Adverse events ‐ during study period Brimonidine vs apraclonidine | no estimate extracted | NR | No studies |
Apraclonidine compared with pilocarpine for temporarily increased IOP after laser trabeculoplasty
Population: people with glaucoma receiving LTP
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IOP increase of ≥ 5 mmHg within 2 hours Apraclonidine vs pilocarpine | no estimate extracted | NR | No studies |
IOP increase of ≥ 10 mmHg within 2 hours Apraclonidine vs pilocarpine | no estimate extracted | NR | No studies |
Mean change in IOP from pre‐LTP within 2 hours Apraclonidine vs pilocarpine | no estimate extracted | 2 studies · 277 participants | Moderate Downgraded: imprecision, inconsistency |
IOP increase of ≥ 5 mmHg between 2 and 24 hours Apraclonidine vs pilocarpine | no estimate extracted | NR | Low Downgraded: imprecision, inconsistency |
IOP increase of ≥ 10 mmHg between 2 and 24 hours Apraclonidine vs pilocarpine | RR 0.87 [0.14, 5.63] | 2 studies · 390 participants | Low Downgraded: imprecision, inconsistency |
Mean change in IOP from pre‐LTP between 2 and 24 hours Apraclonidine vs pilocarpine | no estimate extracted | 2 studies · 277 participants | Low Downgraded: imprecision, inconsistency |
Adverse events ‐ during study period Apraclonidine vs pilocarpine | no estimate extracted | NR | No studies |
Medication given before LTP compared with the same medication given after LTP for temporarily increased IOP after LTP
Population: people with glaucoma receiving LTP
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IOP increase of ≥ 5 mmHg within 2 hours Medication given before LTP vs the same medication given after LTP | no estimate extracted | NR | No studies |
IOP increase of ≥ 10 mmHg within 2 hours Medication given before LTP vs the same medication given after LTP | no estimate extracted | NR | No studies |
Mean change in IOP from pre‐LTP within 2 hours Medication given before LTP vs the same medication given after LTP | no estimate extracted | NR | No studies |
IOP increase of ≥ 5 mmHg between 2 and 24 hours Medication given before LTP vs the same medication given after LTP | RR 0.82 [0.25, 2.63] | 4 studies · 319 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
IOP increase of ≥ 10 mmHg between 2 and 24 hours Medication given before LTP vs the same medication given after LTP | RR 1.55 [0.19, 12.43] | 4 studies · 319 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mean change in IOP from pre‐LTP between 2 and 24 hours Medication given before LTP vs the same medication given after LTP | no estimate extracted | 3 studies · 198 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse events ‐ during study period Medication given before LTP vs the same medication given after LTP | no estimate extracted | NR | No studies |