Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

151 questions · 152 findings · 61 reviews

No studies found 20 · 13.2%GRADE not reported 4 · 2.6%Very low 53 · 34.9%Low 39 · 25.7%Moderate 24 · 15.8%High 12 · 7.9%

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Adverse events · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Serious adverse events 48 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes serious adverse events 48 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Non‐serious adverse events 43 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes non‐serious adverse events 43 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

LAMA add‐on vs long‐acting beta2‐agonists (LABA) add‐on

Adverse events (all) · adults with asthma not well controlled on ICS

Long‐acting muscarinic antagonists (LAMA) add‐on showed no clear difference in adverse events (all) compared with long‐acting beta2‐agonists (LABA) add‐on (moderate certainty).

1 finding from 1 review