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Evidence found and GRADE certainty

1,549 questions · 1,604 findings · 181 reviews

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No studies found 258 · 16.1%GRADE not reported 69 · 4.3%Very low 337 · 21%Low 406 · 25.3%Moderate 410 · 25.6%High 124 · 7.7%

Steroids vs lubricants

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Steroids vs lubricants

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids may leads to higher change in TBUT (seconds) (longer is favored) compared with lubricants (low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Steroids vs lubricants

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs lubricants

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs lubricants

Adverse effect: cataract · people with dry eye

It is very uncertain whether steroids changes adverse effect: new cataract formation ( compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled steroids vs systemic steroids

Death or bronchopulmonary dysplasia at 36 weeks PMA · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).

2 findings from 1 review

Inhaled steroids vs systemic steroids

Diastolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids probably leads to lower diastolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review