Cochrane · systematic review · CD002057
Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm infants
Shah, SS, Ohlsson, A, Halliday, HL, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 36.4%Moderate 7 · 63.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled steroids compared with systemic steroids for BPD (infants randomised at < 72 hours of age)
Population: Neonates with developing BPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or BPD at 36 weeks' postmenstrual age Inhaled steroids vs systemic steroids | RR 1.04 [0.86, 1.26] | 1 study · 292 participants | Moderate |
Inhaled steroids compared with systemic steroids for BPD (infants randomised between 12 and 21 days of age)
Population: Neonates with developing BPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or BPD at 36 weeks' postmenstrual age Inhaled steroids vs systemic steroids | RR 0.94 [0.83, 1.05] | 1 study · 78 participants | Low |
Inhaled steroids compared with systemic steroids for BPD (infants randomised at < 72 hours or between 12 and 21 days of age)
Population: Neonates with developing BPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BPD at 36 weeks' postmenstrual age Inhaled steroids vs systemic steroids | RR 1.08 [0.88, 1.32] | 3 studies · 429 participants | Low |
Hyperglycaemia Inhaled steroids vs systemic steroids | RR 0.86 [0.61, 1.22] | 3 studies · 429 participants | Low |
Hypertension Inhaled steroids vs systemic steroids | RR 0.86 | 3 studies · 429 participants | Low |
Inhaled steroids compared with systemic steroids for BPD ‐ long‐term outcomes at 7 years of age (infants randomised at < 72 hours of age)
Population: Neonates with developing BPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
General conceptual ability (GCA) score at 7 years The test has a standardisation mean of 100 and SD of 15 Inhaled steroids vs systemic steroids | no estimate extracted | 1 study · 74 participants | Moderate |
Moderate/severe disability at 7 years Inhaled steroids vs systemic steroids | RR 1.4 [0.49, 4.01] | 1 study · 74 participants | Moderate |
Death or moderate/severe disability at 7 years Inhaled steroids vs systemic steroids | RR 1.01 [0.65, 1.58] | 1 study · 107 participants | Moderate |
Systolic blood pressure > 95th percentile at 7 years Inhaled steroids vs systemic steroids | RR 0.55 [0.25, 1.23] | 1 study · 70 participants | Moderate |
Diastolic blood pressure > 95th percentile at 7 years Inhaled steroids vs systemic steroids | no estimate extracted | 1 study · 69 participants | Moderate |
Ever diagnosed as asthmatic by 7 years Inhaled steroids vs systemic steroids | RR 0.87 [0.55, 1.39] | 1 study · 73 participants | Moderate |