Cochrane · systematic review · CD015070
Topical corticosteroids for dry eye
Liu, S-H, Saldanha, IJ, Abraham, AG, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
11
No studies
3
Included studies
NR
No studies 3 · 21.4%Ungraded 0 · 0%Very low 5 · 35.7%Low 4 · 28.6%Moderate 2 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Steroids compared with lubricants
Population: people with dry eye
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in patient‐reported symptom scores (lower is favored) Steroids vs lubricants | no estimate extracted | 15 studies · 3654 participants | Moderate Downgraded: risk of bias |
Change in patient‐reported quality of life scores Steroids vs lubricants | no estimate extracted | NR | No studies |
Change in TBUT (seconds) (longer is favored) Steroids vs lubricants | MD 0.7 [0.06, 1.34] | 7 studies · 587 participants | Low Downgraded: risk of bias, inconsistency |
Change in fluorescein corneal staining scores (lower is favored) Steroids vs lubricants | no estimate extracted | 15 studies · 3583 participants | Moderate Downgraded: risk of bias |
Change in tear osmolarity (mOsm/kg) (lower is favored) Steroids vs lubricants | MD 1.6 | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effect: incident elevated IOP ( Steroids vs lubricants | RR 5.96 [1.3, 27.38] | 8 studies · 2264 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effect: new cataract formation ( Steroids vs lubricants | RR 0.34 [0.01, 8.22] | 3 studies · 1205 participants | Very low Downgraded: risk of bias, imprecision |
Steroids compared with cyclosporine A
Population: people with dry eye
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in patient‐reported symptom scores (lower is favored) Steroids vs cyclosporine A | no estimate extracted | 6 studies · 465 participants | Low Downgraded: risk of bias, imprecision |
Change in patient‐reported quality of life scores Steroids vs cyclosporine A | no estimate extracted | NR | No studies |
Change in TBUT (seconds) (longer is favored) Steroids vs cyclosporine A | MD 0.37 | 5 studies · 353 participants | Low Downgraded: risk of bias, imprecision |
Change in fluorescein corneal staining scores (lower is favored) Steroids vs cyclosporine A | SMD 0.05 | 6 studies · 465 participants | Low Downgraded: risk of bias, imprecision |
Change in tear osmolarity (mOsm/kg) (lower is favored) Steroids vs cyclosporine A | MD 5.8 | 1 study · 69 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effect: incident elevated IOP ( Steroids vs cyclosporine A | RR 1.45 [0.25, 8.33] | 4 studies · 331 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effect: new cataract formation Steroids vs cyclosporine A | no estimate extracted | NR | No studies |