Cochrane · systematic review · CD011646
Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease)
Buzzetti, E, Kalafateli, M, Thorburn, D, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
55
current version
GRADE rated
21
No studies
34
Included studies
NR
No studies 34 · 61.8%Ungraded 0 · 0%Very low 20 · 36.4%Low 1 · 1.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Glucocorticosteroids compared with no intervention for alcoholic hepatitis (all severity)
Population: participants with alcoholic hepatitis (all severity)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Glucocorticosteroids vs no intervention | OR 0.85 [0.67, 1.08] | 12 studies · 1147 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Glucocorticosteroids vs no intervention | OR 1 [0.71, 1.39] | 4 studies · 672 participants | Very low Downgraded: risk of bias |
Serious adverse events (proportion) Glucocorticosteroids vs no intervention | OR 1.37 [0.98, 1.93] | 1 study · 546 participants | Very low Downgraded: risk of bias |
Serious adverse events (number) Glucocorticosteroids vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Glucocorticosteroids vs no intervention | no estimate extracted | NR | No studies |
Pentoxifylline compared with no intervention for alcoholic hepatitis (all severity)
Population: participants with alcoholic hepatitis (all severity)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Pentoxifylline vs no intervention | OR 0.77 [0.58, 1.02] | 6 studies · 881 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Pentoxifylline vs no intervention | OR 1.18 [0.81, 1.74] | 1 study · 545 participants | Very low Downgraded: risk of bias |
Serious adverse events (proportion) Pentoxifylline vs no intervention | OR 1.07 [0.76, 1.51] | 1 study · 545 participants | Very low Downgraded: risk of bias |
Serious adverse events (number) Pentoxifylline vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Pentoxifylline vs no intervention | no estimate extracted | NR | No studies |
Colchicine compared with no intervention for alcoholic hepatitis (all severity)
Population: participants with alcoholic hepatitis (all severity)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Colchicine vs no intervention | OR 1.31 [0.47, 3.64] | 2 studies · 139 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Colchicine vs no intervention | OR 3.18 [0.13, 81.01] | 1 study · 69 participants | Very low Downgraded: risk of bias |
Serious adverse events (proportion) Colchicine vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Colchicine vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Colchicine vs no intervention | no estimate extracted | NR | No studies |
Insulin plus glucagon compared with no intervention for alcoholic hepatitis (all severity)
Population: participants with alcoholic hepatitis (all severity)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Insulin plus glucagon vs no intervention | OR 1.14 [0.69, 1.9] | 5 studies · 265 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Insulin plus glucagon vs no intervention | OR 2.57 [0.92, 7.15] | 1 study · 72 participants | Very low Downgraded: risk of bias |
Serious adverse events (proportion) Insulin plus glucagon vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Insulin plus glucagon vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Insulin plus glucagon vs no intervention | no estimate extracted | NR | No studies |
Propylthiouracil compared with no intervention for alcoholic hepatitis (all severity)
Population: participants with alcoholic hepatitis (all severity)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Propylthiouracil vs no intervention | OR 1.16 [0.5, 2.72] | 2 studies · 108 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (proportion) Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Glucocorticosteroids compared with no intervention for severe alcoholic hepatitis
Population: participants with severe alcoholic hepatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Glucocorticosteroids vs no intervention | OR 0.88 [0.63, 1.21] | 2 studies · 607 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Glucocorticosteroids vs no intervention | OR 1.01 [0.71, 1.43] | 2 studies · 607 participants | Very low Downgraded: risk of bias |
Serious adverse events (proportion) Glucocorticosteroids vs no intervention | OR 1.37 [0.98, 1.93] | 1 study · 546 participants | Very low Downgraded: risk of bias |
Serious adverse events (number) Glucocorticosteroids vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Glucocorticosteroids vs no intervention | no estimate extracted | NR | No studies |
Pentoxifylline compared with no intervention for severe alcoholic hepatitis
Population: participants with severe alcoholic hepatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Pentoxifylline vs no intervention | OR 0.8 [0.59, 1.07] | 4 studies · 726 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Pentoxifylline vs no intervention | OR 1.18 [0.81, 1.74] | 1 study · 545 participants | Very low Downgraded: risk of bias |
Serious adverse events (proportion) Pentoxifylline vs no intervention | OR 1.07 [0.76, 1.51] | 1 study · 545 participants | Very low Downgraded: risk of bias |
Serious adverse events (number) Pentoxifylline vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Pentoxifylline vs no intervention | no estimate extracted | NR | No studies |
Anabolic steroids compared with no intervention for alcohol‐related disorders (others)
Population: alcohol‐related disorders (others)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Anabolic steroids vs no intervention | OR 1.29 [0.7, 2.39] | 2 studies · 248 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Anabolic steroids vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (proportion) Anabolic steroids vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Anabolic steroids vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Anabolic steroids vs no intervention | no estimate extracted | NR | No studies |
Antioxidants compared with no intervention for alcohol‐related disorders (others)
Population: alcohol‐related disorders (others)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Antioxidants vs no intervention | OR 1.96 [0.99, 3.89] | 2 studies · 255 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Antioxidants vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (proportion) Antioxidants vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Antioxidants vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Antioxidants vs no intervention | no estimate extracted | NR | No studies |
Colchicine compared with no intervention for alcohol‐related disorders (others)
Population: alcohol‐related disorders (others)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Colchicine vs no intervention | OR 1.11 [0.8, 1.53] | 2 studies · 604 participants | Very low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Colchicine vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (proportion) Colchicine vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Colchicine vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Colchicine vs no intervention | no estimate extracted | NR | No studies |
Propylthiouracil compared with no intervention for alcohol‐related disorders (others)
Population: alcohol‐related disorders (others)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at maximal Propylthiouracil vs no intervention | OR 0.45 [0.26, 0.78] | 2 studies · 423 participants | Low Downgraded: risk of bias |
Early mortality (mortality up to 90 days) Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (proportion) Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Serious adverse events (number) Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |
Health‐related quality of life Propylthiouracil vs no intervention | no estimate extracted | NR | No studies |