Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review

Probiotics used as adjuvants to conventional antifungal drugs vs conventional antifungal drugs

Rate of serious adverse events · non‐pregnant women with vulvovaginal candidiasis

Probiotics used as adjuvants to conventional antifungal drugs showed no clear difference in rate of serious adverse events compared with conventional antifungal drugs (low certainty).

1 finding from 1 review

Vortioxetine vs SNRIs

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

It is very uncertain whether vortioxetine changes drop‐out due to adverse events compared with SNRIs (very low certainty).

1 finding from 1 review

Vortioxetine vs placebo

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

Vortioxetine probably leads to higher drop‐out due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Maternal serious adverse events · pregnant women

The intervention showed no clear difference in maternal serious adverse events (low certainty).

1 finding from 1 review

Usual care vs immunosuppressive withdrawal after monotherapy

Withdrawals due to adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes withdrawal due to adverse events compared with immunosuppressive withdrawal after monotherapy (very low certainty).

1 finding from 1 review