Cochrane · systematic review · CD011520
Vortioxetine for depression in adults
Koesters, M, Ostuzzi, G, Guaiana, G, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 50%Low 3 · 21.4%Moderate 4 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vortioxetine compared to Placebo for adults with Major Depressive Disorder
Population: adults with Major Depressive Disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response Vortioxetine vs Placebo | RR 1.35 [1.22, 1.49] | 14 studies · 6220 participants | Low Downgraded: risk of bias |
Total number of drop‐outs Vortioxetine vs Placebo | RR 1.05 [0.93, 1.19] | 14 studies · 6220 participants | Moderate Downgraded: risk of bias |
Remission Vortioxetine vs Placebo | RR 1.33 [1.15, 1.53] | 14 studies · 6217 participants | Low Downgraded: risk of bias |
Depressive Symptoms Vortioxetine vs Placebo | no estimate extracted | 14 studies · 5566 participants | Very low Downgraded: risk of bias |
Drop‐out due to adverse events Vortioxetine vs Placebo | RR 1.41 [1.09, 1.81] | 14 studies · 6220 participants | Moderate Downgraded: risk of bias |
Drop‐out due to inefficacy Vortioxetine vs Placebo | RR 0.56 [0.34, 0.9] | 14 studies · 6220 participants | Moderate Downgraded: risk of bias |
Tolerability Vortioxetine vs Placebo | RR 1.12 [1.07, 1.16] | 14 studies · 6182 participants | Moderate Downgraded: risk of bias |
Vortioxetine compared to SNRIs for adults with Major Depressive Disorder
Population: adults with Major Depressive Disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response Vortioxetine vs SNRIs | RR 0.91 [0.82, 1] | 8 studies · 3159 participants | Very low Downgraded: risk of bias |
Total number of drop‐outs Vortioxetine vs SNRIs | RR 0.89 [0.73, 1.08] | 8 studies · 3159 participants | Very low Downgraded: risk of bias |
Remission Vortioxetine vs SNRIs | RR 0.89 [0.77, 1.03] | 8 studies · 3155 participants | Very low Downgraded: risk of bias |
Depressive Symptoms Vortioxetine vs SNRIs | no estimate extracted | 8 studies · 2807 participants | Very low Downgraded: risk of bias |
Drop‐out due to adverse events Vortioxetine vs SNRIs | RR 0.74 [0.51, 1.08] | 8 studies · 3159 participants | Very low Downgraded: risk of bias |
Drop‐out due to inefficacy Vortioxetine vs SNRIs | RR 1.52 [0.7, 3.3] | 8 studies · 3159 participants | Very low Downgraded: risk of bias |
Tolerability Vortioxetine vs SNRIs | RR 0.9 [0.86, 0.94] | 8 studies · 3134 participants | Low Downgraded: risk of bias |