Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 473 findings · 205 reviews

No studies found 128 · 27.1%GRADE not reported 49 · 10.4%Very low 142 · 30%Low 106 · 22.4%Moderate 36 · 7.6%High 12 · 2.5%

Perioperative infraorbital nerve block vs Intravenous analgesia

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 1. General ‐ at least one adverse effect compared with low‐potency antipsychotic drugs (moderate certainty).

1 finding from 1 review

Interdisciplinary enhanced rehabilitation (inpatient rehabilitation) vs conventional rehabilitation

Adverse events (postoperative delirium during hospitalisation) · adults with dementia following hip fracture surgery

Interdisciplinary enhanced rehabilitation (inpatient rehabilitation) may leads to lower adverse events (postoperative delirium during hospitalisation) compared with conventional rehabilitation (low certainty).

1 finding from 1 review

Early active flexion plus controlled passive exercise regimen vs controlled passive exercise regimen following surgery

Adverse events: participants incurring one or more adverse events · participants undergoing rehabilitation following surgery for flexor tendon injuries of the handa

It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse events: participants incurring one or more adverse events compared with early controlled passive exercise regimen (very low certainty).

1 finding from 1 review

Yoga vs no exercise

Adverse events (1 participant withdrew due to increased back pain) · patients with non‐specific chronic low back pain

Yoga may leads to higher adverse events (1 participant withdrew due to increased back pain) compared with non‐exercise (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events None of the included studies evaluated adverse events · patients with acute low back pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events None of the included studies evaluated adverse events · patients with acute low back pain

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review

Intervention not reported

Sensitivity analysis: proportion of participants experiencing adverse events. · people with chronic low back pain

The intervention showed no clear difference in sensitivity analysis: proportion of participants experiencing… (moderate certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 2.a. Specific ‐ movement disorders ‐ at least one… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs alternative treatment

Serious adverse events (transfusion‐related adverse effects within 24 hours of the transfusion) · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes serious adverse events (transfusion‐related adverse effects within… compared with alternative treatments (very low certainty).

1 finding from 1 review