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What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 4 reviews · Skin

No studies found 4 · 18.2%GRADE not reported 2 · 9.1%Very low 3 · 13.6%Low 5 · 22.7%Moderate 8 · 36.4%High 0 · 0%

Topical antibiotics with steroids vs topical steroid

Minor adverse events not leading to withdrawal of treatment · people with eczema

It is very uncertain whether topical steroid plus topical antibiotic changes minor adverse events not requiring withdrawal from treatment compared with topical steroid (very low certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir + calamine + cetirizine vs calamine + cetirizine

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Headache. · pityriasis rosea

Acyclovir + calamine + cetirizine showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with calamine + cetirizine (low certainty).

1 finding from 1 review