Cochrane · systematic review · CD013099
Interventions for bacterial folliculitis and boils (furuncles and carbuncles)
Lin, H-S, Lin, P-T, Tsai, Y-S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
35
current version
GRADE rated
11
No studies
23
Included studies
NR
No studies 23 · 65.7%Ungraded 1 · 2.9%Very low 4 · 11.4%Low 4 · 11.4%Moderate 3 · 8.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical antibiotics compared to topical antiseptics for bacterial folliculitis and boils (furuncles and carbuncles)
Population: bacterial folliculitis and boils (furuncles and carbuncles)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure Topical antibiotics vs topical antiseptics | no estimate extracted | NR | No studies |
Severe adverse events leading to withdrawal of treatment Topical antibiotics vs topical antiseptics | no estimate extracted | NR | No studies |
Quality of life Topical antibiotics vs topical antiseptics | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Topical antibiotics vs topical antiseptics | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment Topical antibiotics vs topical antiseptics | no estimate extracted | NR | No studies |
Topical antibiotics compared to systemic antibiotics for bacterial folliculitis and boils (furuncles and carbuncles)
Population: bacterial folliculitis and boils (furuncles and carbuncles)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure Topical antibiotics vs systemic antibiotics | no estimate extracted | NR | No studies |
Severe adverse events leading to withdrawal of treatment Topical antibiotics vs systemic antibiotics | no estimate extracted | NR | No studies |
Quality of life Topical antibiotics vs systemic antibiotics | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Topical antibiotics vs systemic antibiotics | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment Topical antibiotics vs systemic antibiotics | no estimate extracted | NR | No studies |
Phototherapy compared to sham light for bacterial folliculitis and boils (furuncles and carbuncles)
Population: bacterial folliculitis and boils (furuncles and carbuncles)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure Phototherapy vs sham light | no estimate extracted | NR | No studies |
Severe adverse events leading to withdrawal of treatment Phototherapy vs sham light | no estimate extracted | NR | No studies |
Quality of life Phototherapy vs sham light | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Phototherapy vs sham light | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment Phototherapy vs sham light | no estimate extracted | NR | No studies |
Cefadroxil compared to flucloxacillin for bacterial furunculosis
Population: bacterial furunculosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure (measured after 10 days of treatment) Cefadroxil vs flucloxacillin | RR 0.9 [0.7, 1.16] | 1 study · 41 participants | Very low Downgraded: risk of bias, imprecision |
Severe adverse events leading to withdrawal of treatment (reported during 10 days of treatment) Cefadroxil vs flucloxacillin | RR 2.97 [0.6, 14.62] | 1 study · 6514 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Cefadroxil vs flucloxacillin | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Cefadroxil vs flucloxacillin | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment (reported during 10 days of treatment) Cefadroxil vs flucloxacillin | RR 0.78 [0.62, 0.98] | 1 study · 6514 participants | Moderate Downgraded: risk of bias |
Cefdinir compared to cefalexin for bacterial folliculitis and boils (furuncles and carbuncles)
Population: bacterial folliculitis and boils (furuncles and carbuncles)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure (measured 17 to 24 days after treatment) Cefdinir vs cefalexin | RR 1 [0.73, 1.38] | 1 study · 74 participants | Low Downgraded: risk of bias, imprecision |
Severe adverse events leading to withdrawal of treatment (reported during 17 to 24 days of treatment) Cefdinir vs cefalexin | RR 1.05 [0.07, 16.62] | 1 study · 3912 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Cefdinir vs cefalexin | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Cefdinir vs cefalexin | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment Cefdinir vs cefalexin | no estimate extracted | 391 participants | Ungraded |
Azithromycin compared to cefaclor for bacterial boils (furuncles and carbuncles)
Population: bacterial boils (furuncles and carbuncles)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure (measured 7 days after treatment) Azithromycin vs cefaclor | RR 1.01 [0.72, 1.4] | 2 studies · 31 participants | Very low Downgraded: risk of bias, imprecision |
Severe adverse events leading to withdrawal of treatment (reported during 7 days of treatment) Azithromycin vs cefaclor | no estimate extracted | 2 studies · 2744 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life Azithromycin vs cefaclor | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Azithromycin vs cefaclor | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment (reported during 7 days of treatment) Azithromycin vs cefaclor | RR 1.26 [0.38, 4.17] | 2 studies · 2744 participants | Very low Downgraded: risk of bias, imprecision |
Cefditoren pivoxil compared to cefaclor for bacterial boils (furuncles and carbuncles)
Population: bacterial boils (furuncles and carbuncles)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure (measured after 7 days of treatment) Cefditoren pivoxil vs cefaclor | RR 1.17 [0.77, 1.78] | 1 study · 93 participants | Moderate Downgraded: imprecision |
Severe adverse events leading to withdrawal of treatment (reported during 7 days of treatment) Cefditoren pivoxil vs cefaclor | RR 4.74 [0.23, 97.17] | 1 study · 1504 participants | Low Downgraded: imprecision |
Quality of life Cefditoren pivoxil vs cefaclor | no estimate extracted | NR | No studies |
Recurrence of folliculitis or boil following completion of treatment Cefditoren pivoxil vs cefaclor | no estimate extracted | NR | No studies |
Minor adverse events not leading to withdrawal of treatment (reported during 7 days of treatment) Cefditoren pivoxil vs cefaclor | RR 1.52 [0.52, 4.42] | 1 study · 1504 participants | Moderate Downgraded: imprecision |