Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

78 questions · 103 findings · 34 reviews

No studies found 24 · 23.3%GRADE not reported 33 · 32%Very low 15 · 14.6%Low 12 · 11.7%Moderate 17 · 16.5%High 2 · 1.9%

Alitretinoin vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Group A: amino acids vs placebo

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group A: amino acids changes adverse effects: suicidal thoughts Short‐term (events) compared with placebo (very low certainty).

1 finding from 1 review

Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
    4 to 12 months
    SoF 1, Safety of the intervention at 4 to 12 months: '3 studies (1 each evaluating topical acitretin, topical 13-cis-retinoic acid, 200,000 IU per week of vitamin A) found no adverse effects. Systemic 13-cis-retinoic…
    4 studies
    GRADE not reported

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Adverse effects on oral health: Gingival Index (lower arch) · People who had received fixed appliance orthodontic treatment

CAD/CAM nitinol fixed (bonded) retainer showed no clear difference in adverse effects on oral health: Gingival Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (low certainty).

1 finding from 1 review

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Adverse effects on oral health: bleeding on probing (lower arch) · People who had received fixed appliance orthodontic treatment

The review found no eligible studies for this question.

1 finding from 1 review

Cannabidiol vs AMISULPRIDE

Adverse effects: measured adverse events ‐ medium term ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review