Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 20 findings · 11 reviews

No studies found 6 · 30%GRADE not reported 0 · 0%Very low 8 · 40%Low 1 · 5%Moderate 1 · 5%High 4 · 20%

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids plus standard care vs placebo or usual care

Serious adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination

It is very uncertain whether inhaled corticosteroids plus standard care changes serious adverse events compared with standard care (with or without placebo) (very low certainty).

1 finding from 1 review

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ suspected or probable pneumonia · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

1 finding from 1 review