Cochrane · systematic review · CD007074
Anti‐inflammatory medications for obstructive sleep apnoea in children
Kuhle, S, Hoffmann, DU, Mitra, S, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 30%Moderate 4 · 40%High 1 · 10%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Corticosteroids compared to placebo for obstructive sleep apnoea in children
Population: obstructive sleep apnoea in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AHI (number of breathing pauses and episodes of shallow breathing per hour of sleep time) Corticosteroids vs placebo | no estimate extracted | 2 studies · 75 participants | Low Downgraded: inconsistency |
Desaturation index (number of times per hour of sleep time that the blood's O₂ level drops by a certain proportion from baseline) Corticosteroids vs placebo | no estimate extracted | 2 studies · 75 participants | Moderate Downgraded: imprecision, inconsistency |
Respiratory arousal index (number of times per hour of sleep time that an increased respiratory effort without a decrease in oxygen saturation is recorded) Corticosteroids vs placebo | no estimate extracted | 2 studies · 75 participants | Low Downgraded: imprecision, inconsistency |
Nadir SpO₂ (lowest SpO₂ during sleep) Corticosteroids vs placebo | no estimate extracted | 2 studies · 75 participants | Moderate Downgraded: imprecision, inconsistency |
Serious adverse events (N experiencing events) Corticosteroids vs placebo | no estimate extracted | NR | No studies |
Montelukast compared to placebo for obstructive sleep apnoea in children
Population: obstructive sleep apnoea in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AHI (number of breathing pauses and episodes of shallow breathing per hour of sleep time) Montelukast vs placebo | no estimate extracted | 2 studies · 103 participants | Moderate Downgraded: inconsistency |
Desaturation index (number of times per hour of sleep time that the blood's O₂ level drops by a certain proportion from baseline) Montelukast vs placebo | no estimate extracted | 2 studies · 103 participants | Low Downgraded: imprecision, inconsistency |
Respiratory arousal index (number of times per hour of sleep time that an increased respiratory effort without a decrease in oxygen saturation is recorded) Montelukast vs placebo | no estimate extracted | 2 studies · 103 participants | Moderate Downgraded: imprecision, inconsistency |
Nadir SpO₂ (lowest SpO₂ during sleep) Montelukast vs placebo | no estimate extracted | 2 studies · 103 participants | High |
Serious adverse events (N experiencing event) Montelukast vs placebo | no estimate extracted | NR | No studies |