Cochrane · systematic review · CD015125
Inhaled corticosteroids for the treatment of COVID‐19
Griesel, M, Wagner, C, Mikolajewska, A, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled corticosteroids plus standard care compared to standard care (with or without placebo) for adults with a confirmed diagnosis of mild COVID‐19
Population: adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | RR 0.61 [0.22, 1.67] | 3 studies · 2132 participants | Low Downgraded: imprecision |
Admission to hospital or death Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | RR 0.72 [0.51, 0.99] | 2 studies · 2025 participants | Moderate Downgraded: imprecision |
Symptom resolution: all initial symptoms resolved at day 14 Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | RR 1.19 [1.09, 1.3] | 2 studies · 1986 participants | Moderate Downgraded: risk of bias |
Symptom resolution: duration to symptoms resolved Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | no estimate extracted | 1 study · 139 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | RR 0.51 [0.09, 2.76] | 1 study · 1586 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | RR 0.78 [0.47, 1.31] | 1 study · 400 participants | Low Downgraded: risk of bias, imprecision |
Infections Inhaled corticosteroids plus standard care vs standard care (with or without placebo) | RR 0.88 [0.3, 2.58] | 1 study · 400 participants | Low Downgraded: imprecision |