Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 209 findings · 31 reviews

No studies found 35 · 16.7%GRADE not reported 68 · 32.5%Very low 67 · 32.1%Low 18 · 8.6%Moderate 16 · 7.7%High 5 · 2.4%

Chlorhexidine varnish vs placebo or no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine 0.2% vs Normal saline

Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine 0.2% vs Normal saline

Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
1 finding from 1 review

Chlorhexidine 0.2% vs Normal saline

Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine mouthrinse vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine toothpaste vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine gel (0.12%) vs no treatment

Mutans streptococci prevalence (presence/absence) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

It is very uncertain whether chlorhexidine gel (0.12%) changes mutans streptococci prevalence (presence/absence) compared with no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine gel (0.12%) vs no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine gel (0.12%) vs no treatment

Presence of new caries in the primary teeth · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

It is very uncertain whether chlorhexidine gel (0.12%) changes presence of new caries in the primary teeth compared with no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine chewing gum vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine vs Essential oils/herbal mouthwash

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

Chlorhexidine (CHX) led to lower reduction in level of contamination by particles >5 um (droplets) at… compared with essential oils/herbal mouthwash; GRADE not reported.

4 findings from 1 review
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Chlorhexidine vs Cetylpyridinium chloride (CPC)

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with cetylpyridinium chloride (CPC) (very low certainty).

9 findings from 1 review
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Chlorhexidine vs Water (distilled)

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
5 findings from 1 review
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Chlorhexidine vs povidone‐iodine

Reduction in level of contamination by particles <=5 um (droplet nuclei) at >=2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles <=5 um (droplet… compared with povidone iodine (very low certainty).

2 findings from 1 review

Chlorhexidine vs Ozonated water

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with ozonated water (very low certainty).

1 finding from 1 review