Question · asked by 1 review
Chlorhexidine vs Water (distilled): Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity
- Population
- Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
- Intervention
- Chlorhexidine
- Comparison
- Water (distilled)
- Outcome
- Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with water (distilled) (very low certainty).
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 3 · 60%Very low 1 · 20%Low 1 · 20%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Chlorhexidine (CHX) vs Water (distilled) Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · operator level Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental… (2022) · Cochrane All outcomes | At operator level, because of high heterogeneity (I2 = 98%), the results were not meta-analysed (6 studies, 196 participants). No pooled estimate or GRADE rating. | 6 studies · 196 participants | GRADE not reported |
Chlorhexidine (CHX) vs Water (distilled) Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · combined patient and operator level It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with water (distilled) (very low certainty). Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental… (2022) · Cochrane All outcomes | MD -632.94 [-1267.33, 1.45] | 3 studies · 80 participants | Very low |
Chlorhexidine (CHX) vs Water (distilled) Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · tempered CHX; combined operator, assistant and patient level Chlorhexidine (CHX) may leads to lower reduction in level of contamination by particles >5 um (droplets) at… compared with water (distilled) (low certainty). Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental… (2022) · Cochrane All outcomes | MD -101.1 [-107.01, -95.19] | 1 study · 20 participants | Low |
Chlorhexidine (CHX) vs Water (distilled) Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · patient level (pharynx; not analysed) Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental… (2022) · Cochrane All outcomes | Bay 1993 compared 0.12% CHX with distilled water (30-second rinse) and evaluated the outcome at patient level (Andersen's level 2, oropharynx); the data were not included in the meta-analysis. No pooled estimate or… | 1 study | GRADE not reported |
Chlorhexidine (CHX) vs Water (distilled) Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them · assistant level Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental… (2022) · Cochrane All outcomes | At assistant level, because of high heterogeneity (I2 = 96%), the results were not meta-analysed (4 studies, 136 participants). No pooled estimate or GRADE rating. | 4 studies · 136 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers 2022 · Cochrane All outcomes | 2022-02 | Not listed | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.