Cochrane · intervention · CD008948

Irrigants for non‐surgical root canal treatment in mature permanent teeth

Fedorowicz, Z, Nasser, M, Sequeira‐Byron, P, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library

Oral Health Endodontics and dental trauma2 versionsAMSTAR 2: not assessed

Full textEvery question was extracted from the full review (methods and results), not only its Summary of Findings table.

Questions

current version

GRADE rated

No studies

Included studies

as reported

No studies 58 · 82.9%Ungraded 12 · 17.1%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Review question

Element	Planned (methods)	Found (results)
Population	Any age involving single or multi-rooted permanent teeth with pulpal or periapical pathology or both which required root canal treatment (single or multiple visit). Only teeth with fully formed roots were considered	A total of 851 participants were investigated and provided 879 teeth. The age of the participants ranged from 14 to 78 years and included both genders
Intervention	Any irrigants either against each other or against inactive agent (irrigant) or placebo. Combinations of irrigants were acceptable and if they had been used in conjunction with EDTA (ethylenediaminetetra-acetic acid) or similar chelating agents	Sodium hypochlorite (n=4); Chlorhexidine (n=4); Sodium hypochlorite with hydrogen peroxide (n=1); Sodium hypochlorite with proteolytic enzyme (n=1); Sodium hypochlorite with EDTA (n=1); Sodium hypochlorite with MTAD (n=2); Normal saline (n=3)
Comparison	Inactive agent (irrigant)/placebo	Normal saline (n=3); Chlorhexidine (n=4); Sodium hypochlorite (n=4); Hydrogen peroxide (n=1); Proteolytic enzyme (n=1); EDTA (n=1); MTAD (n=1)
Outcomes	Proportion of participants with moderate to severe pain in the time period: 72 hours to 14 days following the procedure. Proportion of participants with new or worsening signs symptoms or both of inflammation requiring a revisit at any time point up to 14 days following the procedure. Proportion of participants with moderate to severe pain up to 6 hours following the procedure. The mean change in health-related quality of life or participant-expressed satisfaction with the procedure. Proportion of participants or 'samples' with positive bacterial growth culture following the procedure and until 72 hours at follow-up. Change in periapical radiolucency as assessed by radiography or cone beam computed tomography (CBCT) at any clinically relevant time points and up to 1 year post-endodontic treatment	Proportion of participants with moderate to severe pain 72 hours to 14 days (n=2); Proportion of participants with new or worsening signs symptoms of inflammation (n=2); Proportion of participants with moderate to severe pain up to 6 hours (n=1); Proportion of participants or samples with positive bacterial growth culture (n=7); Change in periapical radiolucency (n=0)
Study designs	Randomised controlled trials (RCT) in which the unit of randomisation was an individual participant or tooth. If the unit of analysis was an individual person with more than one treated tooth this study would be considered a cluster RCT	NR
Timing	Not reported	Not reported

Search date: 2012-07. Databases: Cochrane Oral Health Group's Trials Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE (1950 to 5 July 2012); EMBASE (1980 to 5 July 2012); Latin American and Caribbean Literature on Health Sciences (LILACS)