Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Sealapex (eugenol-free calcium hydroxide) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Sealapex (eugenol-free calcium hydroxide) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.
1 finding from 1 review
Hip Fracture · post‐menopausal women and older people at risk of osteoporotic fractures
Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining new hip fracture (1 year estimate) compared with control or placebo (high certainty).
1 finding from 1 review
Persons sustaining new non‐vertebral fracture (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures
1 finding from 1 review
Fractures: vertebral or deformity · post‐menopausal women and older people at risk of osteoporotic fractures
1 finding from 1 review
New fractures · post‐menopausal women and older people at risk of osteoporotic fractures
Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Electrofulguration + calcium hydroxide (CH) showed no clear difference in clinical failure compared with electrofulguration + zinc oxide and eugenol (ZOE); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Electrofulguration + calcium hydroxide (CH) showed no clear difference in radiological failure compared with electrofulguration + zinc oxide and eugenol (ZOE); GRADE not reported.
1 finding from 1 review
Enamel resistance to demineralization (microhardness / lesion depth) · Extracted human teeth with early/artificial enamel lesions (in vitro)
Low-quality in vitro evidence suggests remineralising additives may reduce mineral loss, but no firm conclusion can be drawn.
1 finding from 1 review
no estimate extracted
4 studies
GRADE not reported
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) + calcium hydroxide showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)
Calcium sulphate grafting of the periapical lesion showed no clear difference in healing - 1 year compared with no grafting (low certainty).
1 finding from 1 review
Remineralisation of early enamel caries · Children with early enamel caries (permanent dentition)
One trial found 6% sodium fluoride plus 6% calcium fluoride varnish significantly reversed early enamel caries versus no treatment; ungraded and not meta-analysed.
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single triple-blinded RCT found the ACP-containing adhesive reduced enamel demineralization versus a conventional adhesive over 6 months (ungraded).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Fluorine showed no significant difference in 24 h bond strength (MD 2.140, 95% CI -1.506 to 5.787; Moderate certainty).
2 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Control showed no significant difference in 24 h bond strength (MD 1.539, 95% CI -1.738 to 4.817; Moderate certainty).
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single small split-mouth RCT found the nCaF2-containing primer reduced demineralization (DIAGNOdent) but showed no significant clinical white spot lesion difference at debonding (ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure
Partial pulpotomy with MTA or Biodentine had a pooled success rate of 86.8%.
1 finding from 1 review
Whitening (bleaching) efficacy · Demineralised / white-spot-lesion enamel (in vitro specimens)
Low-quality in vitro evidence indicates that adding fluoride or other remineralising agents does not impair the whitening/bleaching effect (ungraded).
1 finding from 1 review
Enamel mineral loss / remineralisation · Demineralised / white-spot-lesion enamel (in vitro specimens)
Low-quality in vitro evidence indicates that adding fluoride, calcium or CPP-ACP to bleaching agents can reduce enamel mineral loss (ungraded).
1 finding from 1 review