Vitamin D plus calcium vs placebo or control: New fractures
Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo Persons sustaining any new fracture (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty). Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men (2014) · Cochrane Headline outcomes only | RR 0.95 [0.9, 0.99] | 10 studies · 49976 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.