Cochrane · systematic review · CD000227
Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men
Avenell, A, Mak, JCS, O'Connell, DL · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Bone, Joint and Muscle TraumaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 1 · 14.3%High 5 · 71.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vitamin D [D2, D3 or 25(OH)D] plus calcium compared with control or placebo for preventing fractures in older people
Population: post‐menopausal women and older people at risk of osteoporotic fractures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persons sustaining new hip fracture (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | RR 0.84 [0.74, 0.96] | 9 studies · 49853 participants | High |
Persons sustaining new non‐vertebral fracture (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | 0.86 [0.78, 0.96] | 8 studies · 10380 participants | High |
Persons sustaining new vertebral fracture or deformity (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | 0.89 [0.74, 1.09] | 4 studies · 42185 participants | Moderate |
Persons sustaining any new fracture (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | RR 0.95 [0.9, 0.99] | 10 studies · 49976 participants | High |
Persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | RR 3.29 [0.37, 29.14] | 2 studies · 3853 participants | Low |
Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | RR 1.17 [1.03, 1.34] | 2 studies · 39552 participants | High |
Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) Vitamin D [D2, D3 or 25(OH)D] plus calcium vs control or placebo | RR 0.94 [0.87, 1.02] | 6 studies · 46794 participants | High |