Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent): Enamel resistance to demineralization (microhardness / lesion depth)
- Population
- Extracted human teeth with early/artificial enamel lesions (in vitro)
- Intervention
- Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP)
- Comparison
- Bleaching alone (no remineralising agent)
- Outcome
- Enamel resistance to demineralization (microhardness / lesion depth)
Low-quality in vitro evidence suggests remineralising additives may reduce mineral loss, but no firm conclusion can be drawn.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Bleaching plus fluoride, calcium, or CPP-ACP vs Bleaching without a remineralising additive Mineral loss, lesion depth, or enamel microhardness · Extracted human teeth with artificial white spot lesions · Varied or not stated, laboratory setting Low-quality in vitro evidence suggests remineralising additives may reduce mineral loss, but no firm conclusion can be drawn. Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. (2020) All outcomes | no estimate extracted | 4 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes | 2018-07-01 | 15 | Low / Critically Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Effect of 10% carbamide peroxide bleaching on sound and artificial enamel carious lesions · 2009 · included by 1 of these review
- Susceptibility to carieslike lesions after dental bleaching with different techniques. · 2007 · included by 1 of these review
- The effect of bleaching on enamel susceptibility to acid erosion and demineralisation · 2005 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.