Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent): Enamel mineral loss / remineralisation
- Population
- Demineralised / white-spot-lesion enamel (in vitro specimens)
- Intervention
- Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP)
- Comparison
- Bleaching alone (no remineralising agent)
- Outcome
- Enamel mineral loss / remineralisation
Low-quality in vitro evidence indicates that adding fluoride, calcium or CPP-ACP to bleaching agents can reduce enamel mineral loss (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent) Enamel mineral loss / remineralisation · Demineralised / white-spot-lesion enamel (in vitro specimens) · In vitro laboratory studies Low-quality in vitro evidence indicates that adding fluoride, calcium or CPP-ACP to bleaching agents can reduce enamel mineral loss (ungraded). Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. (2020) All outcomes | Inconclusive: F/Ca/CPP-ACP additives reduced mineral loss on SOUND enamel (refs 8,10,16) but not verified for artificial caries lesions (ref 35) | 4 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes | 2018-07-01 | 15 | Low / Critically Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Role of fluoridated carbamide peroxide whitening gel in the remineralization of demineralized enamel: An in vitro study. · 2014 · included by 1 of these review
- Effects of the Addition of Fluoride and Calcium to Low-Concentrated Carbamide Peroxide Agents on the Enamel Surface and Subsurface · 2011 · included by 1 of these review
- Remineralization Potential of a Fluoridated Carbamide Peroxide Whitening Gel · 2006 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.