Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

420 questions in 57 reviews · Gut

current versions
No studies 420 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Biofeedback vs relaxation training
Serious adverse events (SAE) · people with irritable bowel syndrome
Biofeedback for treatment of irritable bowel syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Biofeedback plus standard therapy vs sham biofeedback plus standard therapy
Quality of life (QoL) · people with irritable bowel syndrome
Biofeedback for treatment of irritable bowel syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Biofeedback plus standard therapy vs sham biofeedback plus standard therapy
Adverse events (AE) · people with irritable bowel syndrome
Biofeedback for treatment of irritable bowel syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Biofeedback plus standard therapy vs sham biofeedback plus standard therapy
Serious adverse events (SAE) · people with irritable bowel syndrome
Biofeedback for treatment of irritable bowel syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs placebo
Pain · participants with active and inactive inflammatory bowel disease
Adjuvant therapy with antidepressants for the management of inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Infertility at 24 months · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Miscarriage · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Stillbirth · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Use of ART · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Caesarean section · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Preterm delivery · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Low birth weight · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Laparoscopic vs open surgery
Small for gestational age · females with inflammatory bowel disease
The impact of surgical therapies for inflammatory bowel disease on female fertility (2019) · Cochrane
no estimate extractedNRNo studies
Antibiotic with anti‐TNF vs placebo with anti‐TNF
Failure to maintain endoscopic remission · Participants with active CD
Antibiotics for induction and maintenance of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
Antibiotic with anti‐TNF vs placebo with anti‐TNF
Serious adverse events · Participants with active CD
Antibiotics for induction and maintenance of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
Antibiotic vs placebo
Failure to maintain endoscopic remission · Participants with active CD
Antibiotics for induction and maintenance of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
Antibiotic with anti‐TNF vs placebo with anti‐TNF
Failure to enter clinical remission · Participants with active CD
Antibiotics for induction and maintenance of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
Antibiotic with anti‐TNF vs placebo with anti‐TNF
Failure to maintain clinical remission · Participants with active CD
Antibiotics for induction and maintenance of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention diet vs control diet
Health‐related quality of life · people with inactive Crohn's disease
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention diet vs control diet
Adverse events · people with inactive Crohn's disease
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention diet vs control diet
Health‐related quality of life · people with active ulcerative colitis
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention diet vs control diet
Adverse events · people with active ulcerative colitis
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention diet vs control diet
Adverse events · Participants with inactive ulcerative colitis
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention diet vs control diet
Adverse events · people with active Crohn's disease
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
OutcomesAnalysis 1.4 · Patients with active Crohn's disease
Adalimumab for induction of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Endoscopic response · Patients with active Crohn's disease
Adalimumab for induction of remission in Crohn's disease (2019) · Cochrane
no estimate extractedNRNo studies
High‐volume continuous veno‐venous hemofiltration (CVVH) vs standard CVVH
Length of hospital stay · adults with severe acute pancreatitis
Continuous veno‐venous hemofiltration for severe acute pancreatitis (2019) · Cochrane
no estimate extractedNRNo studies
High‐volume continuous veno‐venous hemofiltration (CVVH) vs standard CVVH
Total hospital cost · adults with severe acute pancreatitis
Continuous veno‐venous hemofiltration for severe acute pancreatitis (2019) · Cochrane
no estimate extractedNRNo studies
High‐volume continuous veno‐venous hemofiltration (CVVH) vs standard CVVH
Quality of life · adults with severe acute pancreatitis
Continuous veno‐venous hemofiltration for severe acute pancreatitis (2019) · Cochrane
no estimate extractedNRNo studies
Continuous veno‐venous hemofiltration (CVVH) vs no CVVH
Adverse events · adults with severe acute pancreatitis
Continuous veno‐venous hemofiltration for severe acute pancreatitis (2019) · Cochrane
no estimate extractedNRNo studies
Continuous veno‐venous hemofiltration (CVVH) vs no CVVH
Quality of life · adults with severe acute pancreatitis
Continuous veno‐venous hemofiltration for severe acute pancreatitis (2019) · Cochrane
no estimate extractedNRNo studies
High‐volume continuous veno‐venous hemofiltration (CVVH) vs standard CVVH
Length of ICU stay · adults with severe acute pancreatitis
Continuous veno‐venous hemofiltration for severe acute pancreatitis (2019) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs no supplementation
Change in height · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs no supplementation
Change in quality of life · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs 6‐MP
Change in weight · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs 6‐MP
Change in height · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs 6‐MP
Change in quality of life · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs polymeric formula supplements
Change in weight · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs 6‐MP
Withdrawal due to adverse events · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs mesalamine
Change in height · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs mesalamine
Change in quality of life · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs mesalamine
Adverse events · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs mesalamine
Serious adverse events · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Enteral nutrition vs mesalamine
Withdrawal due to adverse events · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs polymeric formula supplements
Change in height · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs polymeric formula supplements
Change in quality of life · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs polymeric formula supplements
Adverse events · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs polymeric formula supplements
Serious adverse events · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Elemental formula supplements vs no supplementation
Change in weight (kg) · Participants with Crohn's disease in remission
Enteral nutrition for maintenance of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies
Three infusions of natalizumab (300 mg) and two infusions of infliximab (5 mg/kg) vs placebo and two infusions of infliximab
Failure to induce clinical response at 10 weeks · Participants with active Crohn's disease despite current treatment with infliximab
Natalizumab for induction of remission in Crohn's disease (2018) · Cochrane
no estimate extractedNRNo studies