Cochrane · systematic review · CD012680
Adjuvant therapy with antidepressants for the management of inflammatory bowel disease
Mikocka‐Walus, A, Prady, SL, Pollok, J, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
8
No studies
1
Included studies
NR
No studies 1 · 11.1%Ungraded 0 · 0%Very low 1 · 11.1%Low 7 · 77.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressants compared to placebo for inflammatory bowel disease
Population: participants with active and inactive inflammatory bowel disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anxiety at 12 weeks Antidepressants vs placebo | no estimate extracted | 1 study · 44 participants | Low Downgraded: imprecision |
Anxiety at 12 months Antidepressants vs placebo | no estimate extracted | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Depression at 12 weeks Antidepressants vs placebo | no estimate extracted | 1 study · 44 participants | Low Downgraded: imprecision |
Depression at 12 months Antidepressants vs placebo | no estimate extracted | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Adverse events at 12 months Antidepressants vs placebo | RR 2.29 [0.78, 6.73] | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Antidepressants vs placebo | no estimate extracted | 2 studies · 70 participants | Low Downgraded: imprecision |
Pain Antidepressants vs placebo | no estimate extracted | NR | No studies |
Maintenance of remission at 12 months Antidepressants vs placebo | RR 0.96 [0.55, 1.69] | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Endoscopic relapse at 12 months Antidepressants vs placebo | RR 0.14 [0.01, 2.65] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |