Cochrane · systematic review · CD012730
Antibiotics for induction and maintenance of remission in Crohn's disease
Townsend, CM, Parker, CE, MacDonald, JK, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
5
Included studies
NR
No studies 5 · 35.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 35.7%Moderate 2 · 14.3%High 2 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotic compared to placebo for induction and maintenance of remission in Crohn's disease
Population: Participants with active CD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to enter clinical remission Antibiotic vs placebo | RR 0.86 [0.76, 0.98] | 7 studies · 773 participants | High |
Failure to maintain clinical remission Antibiotic vs placebo | RR 0.87 [0.52, 1.47] | 2 studies · 155 participants | Low Downgraded: imprecision |
Failure to achieve clinical response Antibiotic vs placebo | RR 0.77 [0.64, 0.93] | 5 studies · 617 participants | Moderate Downgraded: imprecision, inconsistency |
Failure to maintain endoscopic remission Antibiotic vs placebo | no estimate extracted | NR | No studies |
Adverse events Antibiotic vs placebo | RR 0.87 [0.75, 1.02] | 9 studies · 852 participants | High |
Serious adverse events Antibiotic vs placebo | RR 1.7 [0.29, 10.01] | 3 studies · 520 participants | Low Downgraded: imprecision, inconsistency |
Withdrawal due to adverse events Antibiotic vs placebo | RR 0.86 [0.57, 1.29] | 9 studies · 858 participants | Low Downgraded: imprecision, inconsistency |
Antibiotic with anti‐TNF compared to placebo with anti‐TNF for induction of remission in Crohn's disease
Population: Participants with active CD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to enter clinical remission Antibiotic with anti‐TNF vs placebo with anti‐TNF | no estimate extracted | NR | No studies |
Failure to maintain clinical remission Antibiotic with anti‐TNF vs placebo with anti‐TNF | no estimate extracted | NR | No studies |
Failure to achieve clinical response or remission Antibiotic with anti‐TNF vs placebo with anti‐TNF | RR 0.57 [0.29, 1.1] | 2 studies · 100 participants | Low Downgraded: imprecision |
Failure to maintain endoscopic remission Antibiotic with anti‐TNF vs placebo with anti‐TNF | no estimate extracted | NR | No studies |
Adverse events Antibiotic with anti‐TNF vs placebo with anti‐TNF | RR 0.93 [0.76, 1.12] | 2 studies · 100 participants | Moderate Downgraded: imprecision |
Serious adverse events Antibiotic with anti‐TNF vs placebo with anti‐TNF | no estimate extracted | NR | No studies |
Withdrawal due to adverse events Antibiotic with anti‐TNF vs placebo with anti‐TNF | RR 0.82 [0.19, 3.45] | 2 studies · 100 participants | Low Downgraded: imprecision |