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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

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No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Conventional bitewing radiography, F-speed film vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional F-speed bitewing radiography had a summary ROC AUC of 0.72 for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
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Visual or visual-tactile classification systems (any system: ICDAS, ERK, Nyvad, Downer, Lussi, UniViSS, or unspecified) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
10 findings from 1 review
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TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT/CC genotype vs TT genotype (dominant model)

Dental caries susceptibility · Children and adults (no age limit) assessed for dental caries susceptibility

No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the dominant (CT/CC vs TT) model (OR 1.37, 95% CI 0.81 to 2.33); ungraded.

6 findings from 1 review
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Analogue (conventional) radiographs vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Fluoride-releasing glass ionomer-based bonding agent vs Non-fluoride glass ionomer-based bonding agent

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

For a glass-ionomer-based bonding agent (single study), fluoride release significantly reduced WSL initiation (RR 0.64); subgroup not separately GRADE-rated.

1 finding from 1 review

Laser fluorescence (DIAGNOdent 2190/pen) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, laser fluorescence (DIAGNOdent 2190) had a summary ROC AUC of 0.83 for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
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TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CC genotype vs TT genotype (homozygous model)

Dental caries susceptibility · Children and adults (no age limit) assessed for dental caries susceptibility

No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the homozygous (CC vs TT) model (OR 1.38, 95% CI 0.55 to 3.50); ungraded.

6 findings from 1 review
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Presence of dental plaque vs Absence of dental plaque

Dental caries · Individuals in Ethiopia assessed for dental caries

The presence of dental plaque was not significantly associated with dental caries (OR 5.14, 95% CI 0.67 to 39.39); certainty not graded.

1 finding from 1 review

Conventional bitewing radiography (E-speed film) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional E-speed bitewing radiography had a pooled sensitivity of 0.42 (95% CI 0.28, 0.57) for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
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Chemotherapy regimen A (+/- locoregional treatment) vs Chemotherapy regimen B (+/- locoregional treatment)

Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review

External control of fluoride concentration vs Not applicable

Water samples with fluoride concentration outside the acceptable range · Brazilian cities with artificially fluoridated public water supplies

After excluding Silva et al., the pooled prevalence outside the acceptable range was 47.1%.

1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Overall survival, induction cisplatin + 5-fluorouracil + docetaxel prior to concurrent chemoradiation (cisplatin) vs concurrent chemoradiation (cisplatin) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction cisplatin + 5-fluorouracil + docetaxel… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).

1 finding from 1 review

Laser fluorescence (DIAGNOdent 2095) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

In in vitro, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.81 for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
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Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower locoregional control, induction cisplatin + 5-fluorouracil +… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.

1 finding from 1 review