Dental caries · Children (<18 years) with vs without dental caries
Recessive model (CC vs CT+TT) at FokI(rs10735810) showed no significant association with caries (OR 1.23, 95% CI 0.97-1.55); ungraded.
1 finding from 1 review
Dental caries prevalence · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
The evidence is very uncertain about the effect of obesity on caries odds in the primary dentition (very low certainty).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
Silver diamine fluoride (SDF) showed no clear difference in caries arrest compared with silver nitrate plus fluoride varnish (low certainty).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction before age 8 (vs after 10) increases odds of space closure (OR 5.01; low certainty).
1 finding from 1 review
GtfB/C and F-ATPase activity · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry proanthocyanidins downregulate GtfB/C and F-ATPase activity of S. mutans (5 studies; ungraded).
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
2 findings from 1 review
1 study reported no adverse effects. 1 study reported a white discolouration of the gingiva adjacent to surfaces treated with SDF (116 surfaces) as well as redness (4 surfaces), and mild ulceration (2 surfaces). In…
2 studies · 316 participants
Very low
1 study reported 3 adverse effects in the first 48 hours. Of these, 1 effect in SDF group was possibly related to treatment (spot on corner of lip that looked like a burn), and 2 effects in placebo group were possibly…
3 studies · 983 participants
Very low
Dental caries · Children (<18 years) with vs without dental caries
ApaI(rs7975232) over-dominant model: CC+AA vs CA was not significantly associated with dental caries (OR 0.91); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
MTA and TotalFill BC had comparable pulpotomy success (ungraded).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America
In North America, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -13.28 nmol/l; ungraded).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at age 8-10 (vs after 10) increases odds of space closure (OR 3.32; low certainty).
1 finding from 1 review
Oral disease prevalence · Adult residents of slums and non-slum urban settings of LMICs
Oral disease prevalence was generally high and worse in slum settings where compared, but no meta-analysis was conducted.
1 finding from 1 review
no estimate extracted
18 studies
GRADE not reported
Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; seven included studies reported inhibition of Streptococcus mutans growth with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
7 studies
GRADE not reported
Dental caries in children · Children (approx. 4-18 years)
Waist circumference was not significantly associated with childhood dental caries (pooled OR 1.08, 95% CI 0.90 to 1.30; I2=47.7%); ungraded.
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two studies found adhesive flash-free brackets did not clinically reduce enamel demineralization or white spot lesions versus conventional brackets, though they reduced pathogenic bacteria (ungraded).
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects (tooth staining and other side effects) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).
1 finding from 1 review
Negative predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment
Negative predictive value was reported in 10 studies and ranged widely across studies (about 31% to 99.5%); no pooled estimate and certainty not graded.
1 finding from 1 review
Intervention not reported
Decayed surfaces (DS)
The intervention led to higher decayed surfaces (DS); GRADE not reported.
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, black or brown staining on treated lesions was more common after SDF (OR 3.19, 95% CI 1.95 to 5.23), with no other adverse effects. 1 study reported complaints of a transient bitter taste with SDF use (with…
3 studies · 980 participants
Very low
Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
Obesity may make little or no difference to untreated dental caries (low certainty).
1 finding from 1 review