Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether high-dose vitamin D3 supplementation during pregnancy (2400 IU/day… changes caries presence in primary teeth compared with low-dose (standard) vitamin D supplementation as recommended in… (very low certainty).
1 finding from 1 review
Salivary IL-6 level (pg/mL) · Children and young adults (3-25 years)
Salivary IL-6 levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 11.60 pg/mL, 95% CI 6.27 to 16.94; 11 studies); ungraded.
1 finding from 1 review
Demineralised lesion depth · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation significantly reduced demineralised lesion depth versus untreated control (SMD -0.55, 95% CI -0.97 to -0.12; 3 in vitro studies, I2=62%; ungraded).
1 finding from 1 review
Adverse events for mother or child · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <12 vs ≥12 months was associated with significantly fewer caries (RR 0.65, 95% CI 0.50-0.86), indicating breastfeeding beyond 12 months increases ECC risk (substantial heterogeneity; ungraded).
2 findings from 1 review
Dental caries · Primary school children in Ethiopia
A significant salivary microbial (Lactobacillus) load was associated with higher odds of dental caries (OR 3.82, 95% CI 3.439-4.192; ungraded).
1 finding from 1 review
OR 3.82 [3.439, 4.192]
Studies not reported
GRADE not reported
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Positive predictive value for dental caries diagnosis · Children and adults with primary or permanent dentition
Positive predictive values were reported in 10 of the 13 studies that reported sensitivity and specificity; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
10 studies
GRADE not reported
Dental caries · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
The review found no eligible studies for this question.
2 findings from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at 11-12 vs 8-10 years showed no significant difference in one analysis (OR 0.82; not GRADE-rated).
2 findings from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, Asia
In Asia, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -19.25 nmol/l; ungraded).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies of oral cancer; people assessed for periodontitis
Periodontitis is associated with roughly a threefold higher odds of oral cancer (pooled OR 2.94, 95% CI 2.13-4.07; low certainty of evidence), though heterogeneity is moderate (I2=52.4%).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes caries arrest compared with placebo or no treatment (very low certainty).
3 findings from 1 review
MD 0.20 [0.00, 0.40]
1 study · 373 participants
Very low
MD 0.24 [0.12, 0.36]
1 study · 158 participants
Very low
MD 0.86 [0.39, 1.33]
2 studies · 841 participants
Low
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
One study found mandibular Nolla stage 6-7 associated with better space closure (OR 55.1; single study; not GRADE-rated).
1 finding from 1 review
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
TiO2-modified composite showed no S. mutans difference, with certainty not graded.
1 finding from 1 review
Mother self-reported oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review
Association between orthodontic treatment duration and ICLs prevalence · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
ICLs prevalence increased with longer orthodontic treatment duration (meta-regression P=.01; ungraded).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
Dental caries in children · Adolescents (12-18 years) without background systemic disease
In a subgroup analysis, probiotics reduced the number of caries in adolescents (MD -0.60, 95%CI -0.92 to -0.28; p-interaction=0.02); not GRADE-rated.
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age
Breastfeeding promotion and support (e.g. individually tailored… showed no clear difference in caries presence in primary teeth compared with standard care (low certainty).
1 finding from 1 review