Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Lactobacillus spp. salivary/plaque counts (cariogenic microbiota) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
A meta-analysis found no significant difference in mean Lactobacillus spp. levels between children with and without CLP, with high heterogeneity; the evidence is ungraded.
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in probing pocket depth (PPD) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
2 findings from 1 review
Fluoride ion release · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, the commercial RMGIC Fuji Ortho LC showed significant fluoride release up to 6 months in a single study (ungraded).
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
In the Caucasian ethnicity subgroup, TaqI(rs731236) dominant model: TT+TC vs CC showed no significant association with caries (OR 0.84); ungraded.
8 findings from 1 review
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… 2024 All outcomesDominant model (TT+TC vs CC) · Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India) · Caucasian ethnicity
OR 0.84 [0.50, 1.39]
Studies not reported
GRADE not reported
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… 2024 All outcomesDominant model (TT+TC vs CC) · Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India) · Primary dentition
OR 1.25 [0.08, 20.04]
Studies not reported
GRADE not reported
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… 2024 All outcomesDominant model (TT+TC vs CC) · Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India) · PCR-RFLP genotyping
OR 0.70 [0.47, 1.05]
Studies not reported
GRADE not reported
Show 5 more findings
Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry extract inhibits S. mutans growth in vitro (MIC ~0.5-60 mg/mL across 7 studies; ungraded).
1 finding from 1 review
Cranberry extract inhibited S. mutans growth across ~0.5-25 mg/mL (Abstract): MIC 12.5 mg/dL and MBC 25 mg/dL (Singhal), MIC 60 mg/mL (Sumathi), MIC 0.5-0.75 mg/mL (Prince); 2 mg/mL PAC enhanced photo-irradiated H2O2…
7 studies
GRADE not reported
Dental caries prevalence · Children (<18 years) with intellectual and developmental disabilities (IDD) in India
Dental caries affects about 64% of children with IDD in India (pooled prevalence 0.64, 95% CI 0.45-0.79; high heterogeneity; ungraded).
1 finding from 1 review
Dental caries prevalence · Children aged 2 to 8 years
The review reported 44% dental caries prevalence among children of mothers with low prenatal vitamin D.
2 findings from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
1 finding from 1 review
dmfs index score (decayed, missing, filled primary surfaces; range 0-80) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Advice about a healthy diet (including breastfeeding promotion and… showed no clear difference in dmfs index score (decayed, missing, filled primary surfaces; range… compared with standard care (low certainty).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review
Arun 1994 (n=60): ANB data not usable (no SDs); Mann-Whitney P<0.001 benefit for mandibular headgear. Effect ~0.5 degrees, probably not clinically significant.
1 study · 60 participants
GRADE not reported
Periodontal disease prevalence · Children (<18 years) with intellectual and developmental disabilities (IDD) in India
In the single study reporting it, periodontal disease prevalence was 54.2% (single study; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Children aged ≤6 years (early childhood)
RETRACTED. Among studies before 2017, oral C. albicans presence was associated with higher odds of ECC (OR 4.89, 95% CI 2.79-8.58); ungraded subgroup from a retracted review.
16 findings from 1 review
Show 13 more findings
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): good
OR 5.32 [2.89, 9.80]
7 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: saliva
OR 4.70 [2.44, 9.09]
7 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Overall (all 22 studies, random-effects)
OR 4.42 [3.14, 6.24]
22 studies · 3301 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample size: >=100 (Table 6; abstract text erroneously states '>=1000')
OR 4.65 [2.57, 8.42]
6 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: oral swab
OR 9.55 [2.17, 42.01]
2 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study design: case-control
OR 5.30 [1.72, 16.31]
2 studies · 708 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: Asia
OR 3.62 [2.53, 5.20]
12 studies · 2347 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample size: <100 (Table 6; abstract text erroneously states '<1000')
OR 4.35 [2.75, 6.89]
16 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Time period: 2018 and later
OR 4.17 [2.62, 6.64]
12 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study design: cross-sectional
OR 4.30 [2.92, 6.33]
20 studies · 2593 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): moderate
OR 3.84 [2.24, 6.57]
11 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: America/Canada/Brazil/Chile
OR 3.98 [1.14, 13.87]
5 studies · 319 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomesExposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): low
OR 5.14 [2.12, 12.48]
4 studies
GRADE not reported
Bacterial cell death · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; one included study reported time- and concentration-dependent bacterial-count reduction with cranberry extract.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Reverse Twin Block with lip pads and rapid maxillary expander (RME) led to higher ANB compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review
Muscle pain when chewing · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Serum vitamin D (25(OH)D): ECC vs caries-free
The intervention led to lower serum vitamin D (25(OH)D): ECC vs caries-free; GRADE not reported.
1 finding from 1 review
White spot lesion area · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no significant difference in WSL area, with certainty not graded.
1 finding from 1 review
There was no significant difference in the WSL area between the two groups, with the mean WSL area measuring 161.3 mm2 in the Opal Seal group and 1361.2 mm2 in the conventional group.
1 study · 56 participants
GRADE not reported
Aesthetics · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes aesthetics compared with fluoride varnish (very low certainty).
1 finding from 1 review